A study shows that Covid-19 causes bone marrow lesions
Jan 18, 2024 8:27:37 GMT
Post by shahadat560 on Jan 18, 2024 8:27:37 GMT
Researchers from the Health Research Institute of the Jiménez Díaz Foundation (IIS-FJD) have demonstrated, after carrying out up to 33 'post-mortem' studies limited to lung and bone marrow biopsies during March and April, that Covid-19 infection triggers a uncontrolled inflammatory response mediated by macrophages that, in the bone marrow, show phagocytosis lesions type hemophagocytic syndrome, the basis of macrophage activation syndrome (MAS).
"The cytokines released in this uncontrolled hyperimmune response produce endothelial lesions that lead to the production of microthrombi, such as those present in lung biopsies," explained the doctor from the Pathological Anatomy service of the Madrid hospital and researcher at the IIS-FJD, Miguel Ángel. Piris Pinilla.
In addition to the findings about the bone marrow, which Country Email List constitute the basis for the cytokine storm, the authors of the study, published in the online version of the journal Modern Pathology , already made the results known to the clinical community at the end of March. obtained in lung biopsies, coinciding with those of other European and American teams.
Specifically, these were microthrombi lesions in alveolar capillaries , findings consistent with the respiratory failure that these patients develop. At the time, these findings led to modifications in the therapy that these patients received, helping to introduce anticoagulant therapies. Now, the immunohistochemistry and electron microscopy data, which demonstrate the presence of the coronavirus in type 2 pneumocytes, continue along these lines, as they support treatment with anti-inflammatories and anticoagulants.
Therefore, the work has allowed us to better understand the bases and histological mechanisms of the pathology caused by Covid-19 without the need to perform autopsies at a time when these could not be performed. "It has been received with great interest outside of Spain, for example, in the United States and in several Latin American countries, where they are still in the first wave," said Dr. Piris.
A multidisciplinary study
Caring for Covid-19 patients has eliminated any possible division between many services. In fact, since the beginning of the pandemic and as in numerous other centers, in the case of the Madrid hospital, all its doctors have collaborated with their knowledge and work capacity under the direction of the Infectious Diseases department of its Internal Medicine Service.
"The cytokines released in this uncontrolled hyperimmune response produce endothelial lesions that lead to the production of microthrombi, such as those present in lung biopsies," explained the doctor from the Pathological Anatomy service of the Madrid hospital and researcher at the IIS-FJD, Miguel Ángel. Piris Pinilla.
In addition to the findings about the bone marrow, which Country Email List constitute the basis for the cytokine storm, the authors of the study, published in the online version of the journal Modern Pathology , already made the results known to the clinical community at the end of March. obtained in lung biopsies, coinciding with those of other European and American teams.
Specifically, these were microthrombi lesions in alveolar capillaries , findings consistent with the respiratory failure that these patients develop. At the time, these findings led to modifications in the therapy that these patients received, helping to introduce anticoagulant therapies. Now, the immunohistochemistry and electron microscopy data, which demonstrate the presence of the coronavirus in type 2 pneumocytes, continue along these lines, as they support treatment with anti-inflammatories and anticoagulants.
Therefore, the work has allowed us to better understand the bases and histological mechanisms of the pathology caused by Covid-19 without the need to perform autopsies at a time when these could not be performed. "It has been received with great interest outside of Spain, for example, in the United States and in several Latin American countries, where they are still in the first wave," said Dr. Piris.
A multidisciplinary study
Caring for Covid-19 patients has eliminated any possible division between many services. In fact, since the beginning of the pandemic and as in numerous other centers, in the case of the Madrid hospital, all its doctors have collaborated with their knowledge and work capacity under the direction of the Infectious Diseases department of its Internal Medicine Service.